| 摘要 |
The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM - 10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer , arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chorides and ADAM-10 modulators therefrom.
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| 申请人 |
EXELIXIS INC. |
发明人 |
PRISBYLLA, MICHAEL P.;MAMO, SHUMEYE;NUSS, JOHN M.;XU, WEI;CANNE, LYNNE;CO, ERICK W.;MAC, MORRISON B.;LEW, AMY;KIM, MOON HWAN;BROWN, S. DAVID;LE, DONNA T.;JAMMALAMADAKA, VASU;KHOURY, RICHARD G. |
