The invention provides a method of determining a comparative expression profile in an individual by comparing the expression levels of a sample of molecules in a population of molecules in a speciment from the individual with a health-associated reference expression region of the sample of molecules, wherein expression levels within the health-associated reference expression region indicate a reference expression profile and wherein expression levels outside the health-associated reference expression region indicate a perturbed expression profile. The invention also provides methods of diagnosing a disease or a health state in an individual by comparing the expression level of a sample of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules. The invention additionally provides a method of classifying a population by drug responsiveness.
申请公布号
WO0210456(A3)
申请公布日期
2003.06.26
申请号
WO2001US24036
申请日期
2001.07.30
申请人
THE INSTITUTE FOR SYSTEMS BIOLOGY;HOOD, LEROY, E.;SIEGEL, ANDREW, F.