SMALL-MOLECULE INHIBITORS OF INTERLEUKIN-2

摘要

Compounds of formulae I and I', methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are antagonists of Il-2/IL-2R binding; and are useful for the treatment of interleukin-2 mediated diseases, such as autoimmune diseases (such as rheumatoid arthritis, multiple sclerosis, uveitis, and psoriasis), allograft rejection, and graft-versus-host disease.