Antibacterial compounds

摘要

Compounds of the formula (I) are disclosed which are FabI inhibitors and are useful in the treatment bacterial infections:wherein:R1 is Ar or Het;R2 is H, C1-6alkyl or Ar-C0-6alkyl;X is H, C1-4alkyl, OR', SR', C1-4alkylsulfonyl, C1-4alkylsulfoxyl, CN, N(R')2, CH2N(R')2, NO2, CF3, CO2R', CON(R')2, COR', NR'C(O)R', F, Cl, Br, I, or CF3S(O)r-;R' is H, C1-6alkyl or Ar-C0-6alkyl; andr is 0, 1 or 2;or a pharmaceutically acceptable salt thereof.