METHOD OF PREPARING OXIRACETAM

摘要

PURPOSE: A method of preparing oxiracetam is provided to make oxiracetam product in high purity and yield. The oxiracetam improves brain functions and therapeutic effect on dementia. CONSTITUTION: In a method of preparing oxiracetam of the formula(1), a tri-amide compound of the formula(2) is first prepared by reacting an organic solvent compound of the formula(4) with an organic solvent compound of the formula(5). A compound of the formula(3) is prepared by sequentially conducting cyclization, decarboxylation and reduction with respect to the compound of the formula(2). The compound of the formula(3) reacts with ammonia under the existence of water or alcohol. In the formulae, R is methyl group or ethyl group, and X is hydroxy group or halide. The cyclization of the compound of the formula(2) is achieved by reaction with hydride or alkoxide at -30-50 deg.C for 1-15 hours.