发明名称 |
Diagnostics and vaccines for mycobacterial infections specifically mycobacterium paratuberculosis acylase (mpa) |
摘要 |
A polypeptide comprises the sequence of SEQ ID NO:2 or a polypeptide with at least 70% amino acid identity over 30 amino acids which has mpa activity. A polynucleotide of SEQ ID NO:1 encoding the polypeptide and an antibody specific to the polypeptide are described. Also described are pharmaceutical compositions and vaccines comprising the polypeptides, polynucleotides or antibodies. The presence of a Mycobacterium avium subspecies paratuberculosis (MAP) infection in a biological sample can be detected by providing a nucleic acid probe comprising a polynucleotide of SEQ ID No:1 or an antibody which is bought into contact with the sample and hybridization is allowed to occur. The formation of any nucleic acid duplex or antibody-antigen complex in the sample is detected. The method can be used to detect inflammatory diseases including CrohnÆs disease, JohneÆs disease and sarcoidosis.
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申请公布号 |
NZ507092(A) |
申请公布日期 |
2003.05.30 |
申请号 |
NZ19990507092 |
申请日期 |
1999.03.18 |
申请人 |
ST GEORGEAES HOSPITAL MEDICAL SCHOOL |
发明人 |
HERMON-TAYLOR, JOHN;BULL, TIMOTHY JOHN |
分类号 |
A61K39/00;A61K48/00;C12N9/18;C12N15/55;(IPC1-7):C12N15/55;C12N15/85;C07K16/40;C12N1/20;C12Q1/44;A61K39/04;A61K38/46;G01N33/68;G01N33/569;A61P31/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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