| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide a medicine for preventing and treating bone dysbolism, to provide a method for diagnosing the bone dysbolism, and to provide a kit for using the same. SOLUTION: This antibody binding to a complex (OCIF/sOBM complex) of an osteoclastonenesis inhibitory factor (OCIF) with a soluble OCIF binding molecule (sOBM) present in a body fluid. A hybridoma producing the antibody. The medicine for preventing and treating the bone dysbolism contains the antibody as an active ingredient. The method for diagnosing the bone dysbolism, especially chronic rheumatoid arthritis, by measuring the quantity of the OCIF/ sOBM complex. The kit for diagnosing the bone dysbolism. The antibody can be utilized as an analyzing reagent for diagnosing, preventing, treating or researching the bone dysbolism, especially articular diseases such as chronic rheumatoid arthritis.</p> |
