INJECTABLE DEPOT COMPOSITIONS AND USES THEREOF

摘要

Injectable depot compositions are provided that include a bioerodible, biocompatible polymer, an aromatic alcohol having miscibility in water of less than or equal to 7 wt.% at 25°C, in an amount effective to plasticize the polymer and form a gel therewith, and a beneficial agent. The composition may additionally contain an ester of an aromatic acid, or an aromatic ketone. The compositions are readily implanted beneath a patient's body surface by injection, as the aromatic alcohol not only facilitates solubilization of the polymer, but also acts as a thixotropic agent, substantially increasing the shear thinning behavior of the composition.