4,4-DIFLUORO-1,2,3,4-TETRAHYDRO-5H-1-BENZAZEPINE DERIVATIVES OR SALTS THEREOF

摘要

4,4−Difluoro−1,2,3,4−tetrahy dro−5H−1−benzazepine derivatives represented by the general formula (I), which have excellent arginine vasopressin V2 activity and are useful in the treatment of central diabetes insipidus and/or night pollakisuria: (I) wherein R1 is −OH, −O−lower alkyl, or optionally substituted amino; R2 is lower alkyl which may be substituted with one or more halogen atoms, or halogeno; one of R3 and R4 is −H, lower alkyl, or halogeno, and the other is optionally substituted nonaromatic cyclic amino or optionally substituted aromatic cyclic amino; and R5 is −H, lower alkyl, or halogeno.