| 摘要 |
<p>Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin agr;vbgr;3 are inhibited by an inhibitor compound of formula (I): wherein G1 and G2 are each independently NH C(O) O R1, NH C(O) O (CH2)v (C6H4) X3, NH C(O) NH (CH2)v (C6H4) X3, O C(O) NH (CH2)v (C6H4) X3, O C(O) O (CH2)v (C6H4) X3, or NH C(O) CH2 (C6H4) X3; Y1 and Y2 are each independently OH, C1 C4 alkyl, C1 C4 hydroxyalkyl, C1 C4 alkoxy, phenyl, benzyl, or NH2; R1 is C1 C4 alkyl; X1 and X2 are each independently halo or C1 C4 alkoxy; X3 is halo, nitro, C1 C4 alkyl, C1 C4 alkoxy, or C1 C4 perfluoroalkyl; Z is Cequiv;C , C6H4 , cis CH=CH , trans CH=CH , cis CH2 CH=CH CH2 , trans CH2 CH=CH CH2 , 1, 4 naphthyl, cis 1, 3 cyclohexyl, trans 1, 3 cyclohexyl, cis 1, 4 cyclohexyl, or trans 1,4 cyclohexyl; A is H or a covalent bond; m and n are each independently an integer having a value of 0 or 1; t is an integer having a value of 0 or 1; and p, r, and v are each independently an integer having a value of 1 or 2; with provisos that when A is H, t is O; when A is a covalent bond, t is 1; when m is 0, Y1 is C1 C4 hydroxyalkyl; and when n is 0, Y2 is C1 C4 hydroxyalkyl.</p> |
