发明名称 |
Type 2 methionine aminopeptidase (MetAP2) inhibitors and uses thereof |
摘要 |
Novel compounds that are anti-angiogenic or immunosuppressive are described. Also described are methods for determining if an animal is at risk for a disease involving abnormal angiogenesis or an immune reaction resulting in pathology comprising evaluating an aspect of MetAP2 metabolism or structure; methods for identifying agents that are anti-angiogenic or immunosuppressive comprising evaluating the effect of the agent on an aspect of MetAP2 metabolism; methods for treating a cell having an abnormality in metabolism or structure of MetAP2; and methods for treating abnormal angiogenesis or an immune reaction which results in pathology in an animal. Pharmaceutical compositions are also provided.
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申请公布号 |
US6566541(B2) |
申请公布日期 |
2003.05.20 |
申请号 |
US20010813555 |
申请日期 |
2001.03.21 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
LIU JUN O.;GRIFFITH ERIC C.;SU ZHUANG |
分类号 |
C07D303/02;C07D303/14;C07D495/04;(IPC1-7):C07D303/08;C07D303/18;C07D303/36 |
主分类号 |
C07D303/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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