发明名称 |
Compositions and methods for preventing transepithelial transmission of HIV |
摘要 |
Methods, compositions and articles for blocking transepithelial transmission of HIV with ICAM-1 angonist/antagonists are provided. The ICAM-1 agonist/antagonists block viral transmission at the site of exposure to the virus. Blocking viral transmission does not require blocking the binding of ICAM-1 to LFA-1. The ICAM-1 agonist/antagonists may be applied to mucosal surfaces, on or in contraceptive devices or in oral solutions such as breast milk supplements and infant formula.
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申请公布号 |
US6566095(B1) |
申请公布日期 |
2003.05.20 |
申请号 |
US20000599555 |
申请日期 |
2000.06.23 |
申请人 |
JOHNS HOPKINS UNIVERSITY |
发明人 |
MARKHAM RICHARD B.;KHANNA KRISTEN V. |
分类号 |
A61K9/02;A61K9/06;A61K9/08;A61K9/10;A61K9/12;A61K9/20;A61K39/395;A61P31/18;C07K16/28;C12N5/08;(IPC1-7):C12P21/06;A61K39/42 |
主分类号 |
A61K9/02 |
代理机构 |
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代理人 |
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地址 |
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