| 摘要 |
Chiral phosphane ligands (I) are new. Chiral phosphane ligands of formula (I) are new. R<1> = H, alkyl, alkenyl, (hetero)aromatic aryl, O-alkyl, NH-alkyl, N-(alkyl)2 where the alkyl groups are optionally bonded to each other via an oxygen bridge, O-aryl, NH-aryl or N-(alkyl)(aryl); R<2> - R<9> = R<1> or O-CO-alkyl, O-CO-aryl, F, Cl, Br, OH, NO2, Si(alkyl)3, CF3, CN, CO2H, COH, SO3H, CONH2, CONH(alkyl), CON(alkyl)2, SO2(alkyl), SO(alkyl), SO(aryl), SO2(aryl), SO3(aryl), S-alkyl, S-aryl, NH-CO(alkyl), CO2(alkyl), CONH2, CO(alkyl), NHCOH, NHCO2(alkyl), CO(aryl), CO2(aryl), CONH2, CO(alkyl), NHCOH, NHCO2(alkyl), CO(aryl),CO2(aryl), CHCH-CO2(aryl), CH=CH-CO2H, PO(aryl)2, PO(alkyl)2, PO3H or PO(o-alkyl)2 where two or more neighboring groups are optionally bonded to form a condensed ring system; alkyl = 1-12C alkyl; alkenyl = optionally unsaturated 2-4C alkenyl optionally substituted by Cl, F, 1-12C alkyl, -1-12C alkoxy, 5-10C aryl, 5-10C aryloxy, NH2, 1-12C alkylamine, 1-12C dialkylamine; and aryl = 5-10C aromatic, optionally substituted by Cl, F, 1-12C alkyl, 1-12C alkoxy, 5-10C aryl(oxy), NH2 or 1-12C (di)alkylamine, where 1-4C atoms of the aromatic groups are substituted by N, O or S to form a 5-10 membered heteroaromatic aryl. Independent claims are also included for the following: (1) catalysts prepared by reaction of a metal salt or a metal complex precursor with a ligand of formula (I); and (2) a process for the production of chiral ligands of formula (I) where enantiomer rich dimethyl compounds of formula (II) are lithiated with alkyl lithium compounds, followed by reaction with aminophosphorus dichlorides, alkyl- or arylphosphorus dichlorides.
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