摘要 |
This invention provides polymer conjugates of opioid antagonists comprising a polymer, such as poly(ethylene glycol), covalently attached to an opioid antagonist. The linkage between the polymer and the opioid antagonist is preferably hydrolytically stable. The invention also includes a method of treating one or more side effects associated with the use of opioid analgesics, such as constipation, nausea, or pruritus, by administering a polymer conjugates of the invention. |
申请人 |
SHEARWATER CORPORATION;BENTLEY, MICHAEL, DAVID;ROBERTS, MICHAEL, JAMES;SHEN, XIAOMING;CHENG, LIN |
发明人 |
BENTLEY, MICHAEL, DAVID;ROBERTS, MICHAEL, JAMES;SHEN, XIAOMING;CHENG, LIN |