QUINOLINE OR QUINAZOLINE DERIVATIVES INHIBITING AUTO- PHOSPHORYLATION OF FIBROBLAST GROWTH FACTOR RECEPTORS

摘要

The invention provides novel compounds which exhibit an inhibitory activity against autophosphorylation of FGF receptor family and can inhibit the proliferation of cancer cells through oral or intravenous administration, specifically compounds represented by the general formula ‖ or pharmaceutically acceptable salts or solvates thereof: ‖ wherein X is CH or N Z is O or S Q is NR10, CR11R12, carbonyl, O, S=Om wherein m is 0 to 2, or urea R1, R2 and R3 are each H, OH, halogeno, nitro, amino, alkyl, alkoxy, or the like with the proviso that the alkyl and the alkoxy may be further substituted R4 is H R5, R6, R7 and R8 are each H, halogeno, alkyl, or alkoxy and R9 is a carbocyclic or heterocyclic group which may be substituted.