发明名称 |
General composition framework for ligand-controlled RNA regulatory systems |
摘要 |
The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of an information transmission domain (ITD). The improved ITD eliminates free-floating ends of the switching and the competing strands, and localizes competitive hybridization events to a contiguous strand of competing and switching strands in a strand-displacement mechanism-based switch, thereby improving the kinetics of strand-displacement. The improved regulatory systems have many uses in various biological systems, including gene expression control or ligand-concentration sensing.
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申请公布号 |
US2012165387(A1) |
申请公布日期 |
2012.06.28 |
申请号 |
US20080228665 |
申请日期 |
2008.08.14 |
申请人 |
SMOLKE CHRISTINA D.;WIN MAUNG NYAN;BEISEL CHASE |
发明人 |
SMOLKE CHRISTINA D.;WIN MAUNG NYAN;BEISEL CHASE |
分类号 |
A61K31/7088;A61P31/00;A61P43/00;C07H21/02;C07H21/04;C12N5/02;C12N5/073;C12N5/10;C12N15/63;C12Q1/44 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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