| 摘要 |
The present invention provides compositions and methods for treating disorde rs associated with a response-to-injury process or proliferating cells in a mammal. These tissue disorders are associated with a novel cellular phenotyp e designated as "transition cells" which are described herein, This cellular phenotype is characterized in having an activated erk kinase signaling activity, a stimulated AP-l binding activity, and at least one characteristi c selected from the group consisting of: (a) increased podosome formation, (b) increased flux of intracellular or extracellular hyaluronans or hyaladherins , (c) increased expression of a hyaladherin, (d) an inability to form focal adhesions, (e) increased metalloproteinase activity, and (f) increased expression of a hyaladherin. Example of disorders include multiple sclerosis , diabetes mellitus and restenosis. The methods provided herein include administering to the mammal, an effective amount of a composition that alter s the activity of transition molecules within a cell Transition molecules are shown to be comprised of hyaladherins, hyaluronans and associated molecules that regulate the transitional phenotype. A novel cell culture comprising transition cells is also provided, as well as compositions comprising particular peptides, polypeptides,and antibodies that affect the transitiona l phenotype.
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