发明名称 |
2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors |
摘要 |
The present invention relates to a compound of formula (I): wherein: R3 is selected from the group consisting of 1-napthyl, 2-napthyl and cycloalkylphenyl; and R4 and R5 taken together form a ring having from 5 to 10 carbon atoms. Additionally, the invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal subject, such as a human, wherein increased angiogenesis is desired, comprising administering to a mammal in need of such therapy an effective amount of the aforementioned thiophene selective adenosine A1 allosteric enhancer.
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申请公布号 |
US2003078248(A1) |
申请公布日期 |
2003.04.24 |
申请号 |
US20020151359 |
申请日期 |
2002.05.20 |
申请人 |
LINDEN JOEL M.;OLLSON RAY A.;SCAMMELLS PETER J. |
发明人 |
LINDEN JOEL M.;OLLSON RAY A.;SCAMMELLS PETER J. |
分类号 |
A61K31/381;C07D333/36;C07D333/38;C07D333/66;(IPC1-7):C07D331/02;A61K31/33 |
主分类号 |
A61K31/381 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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