发明名称 |
ELASTASE INHIBITORS |
摘要 |
Naturally occurring novel elastin derived oligopeptides, having the formula AFP, VPG and AGIP, are disclosed. The oligopeptides are strong competitive inhibitors of elastolytic serine proteases, particularly neutrophil elastases. The novel oligopeptides are useful in methods of inhibiting elastolytic serine protease and methods of detecting a disease characterized by elevated activity of elastolytic serine proteases. Methods for determining the severity of diseases characterized by elevated activity of elastolytic serine proteases are also disclosed. |
申请公布号 |
WO03031574(A2) |
申请公布日期 |
2003.04.17 |
申请号 |
WO2002US31739 |
申请日期 |
2002.10.04 |
申请人 |
NORTH SHORE - LONG ISLAND JEWISH RESEARCH INSTITUTE |
发明人 |
RAO, SRINIVASA, K.;MATHRUBUTHAM, MAHESH;KUSHNER, LESLIE;FAUST, GLENN, R. |
分类号 |
A61K38/00;C07K5/083;C07K5/103 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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