发明名称 |
20-HETE ANTAGONISTS AND AGONISTS |
摘要 |
<p>20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z), 8(Z),11(Z),14(Z)-tetraenoic acid, 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid and 20-,21-dimethyl 20-HETE. Preferable 20-HETE antagonists include 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, 19-hydroxynonadeca-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid and 20-hydroxyeicosa 6(Z),15(Z)-dienoic acid.</p> |
申请公布号 |
EP1056449(B1) |
申请公布日期 |
2003.04.16 |
申请号 |
EP19990908425 |
申请日期 |
1999.02.24 |
申请人 |
MCW RESEARCH FOUNDATION, INC.;BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
ROMAN, RICHARD, J.;FALCK, JOHN, R.;ALONSO-GALICIA, MAGDALENA;JACOBS, ELIZABETH, R.;HARDER, DAVID, R. |
分类号 |
A61K45/00;A61K31/00;A61K31/18;A61K31/20;A61K31/201;A61K31/202;A61P1/16;A61P3/10;A61P7/10;A61P9/00;A61P9/02;A61P9/08;A61P9/10;A61P9/12;A61P9/14;A61P13/12;A61P35/00;(IPC1-7):A61K31/20 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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