发明名称 |
MENTHOL DERIVATIVES AND PROCESS FOR PREPARING THE SAME |
摘要 |
The present invention provides a menthol derivative represented by the following Formula 1 and a method for preparing the menthol derivative. The menthol derivative represented by the Formula 1 is prepared by reacting menthol and phosphorous oxychloride with an equivalence ratio of 1:1~1.3 in an organic solvent in the presence of organic base to obtain dichloro[5-methyl-2(mehtylethyl)cylclohexyloxy] phosphino-1-one; and reacting above obtained dichloro[5-methyl-2(mehtylethyl) cylclohexyloxy]phosphino-1-one with 3-amino propanol in the organic solvent in the presence of the organic; then hydrolyzing and crystallizing the product with polar organic solvent. [Formula I]
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申请公布号 |
US2003069209(A1) |
申请公布日期 |
2003.04.10 |
申请号 |
US20020226129 |
申请日期 |
2002.08.23 |
申请人 |
YOO JAE WON;KIM DUCK HEE;MOON SEONG JOON;NOH MIN SOO;KIM SOO HYUN;AN SU SUN;LEE JIN SEON |
发明人 |
YOO JAE WON;KIM DUCK HEE;MOON SEONG JOON;NOH MIN SOO;KIM SOO HYUN;AN SU SUN;LEE JIN SEON |
分类号 |
C07B61/00;A61K8/55;A61Q11/00;A61Q17/00;A61Q19/00;A61Q19/08;C07F9/09;C07F9/117;(IPC1-7):A61K31/685;C07F9/02 |
主分类号 |
C07B61/00 |
代理机构 |
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