BENZENE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND USE THEREOF

摘要

Novel benzene derivatives represented by the general formula (‖), which exhibit vanilloid receptor agonism and are useful as preventive and therapeutic drugs for pollakisuria and urinary incontinence, analgesic, or the like: (‖) wherein R1, R4 and R6 are each independently hydrogen, halogeno, or hydrocarbyl; R2 is hydrocarbyl or a heterocyclic group; R3 is hydrocarbyl, NR7’R7, or OR8 (wherein R7’ is hydrogen or hydrocarbyl and R7 is a non−aromatic group, or alternatively R7’ and R7 together with the nitrogen atom adjacent thereto may form a ring; and R8 is hydrocarbyl or a heterocyclic group); R5 is hydrocarbyl or a heterocyclic group (except quinolyl) and R5’ is hydrogen or hydrocarbyl, or R5 and R5’ together with the nitrogen atom adjacent thereto may form a ring; and R5’’ is hydrogen or hydrocarbyl.