ANTI-HIV AGENT

摘要

A polypeptide containing at least one of the following modular structures (1) to (3) and having the ability to bind to the N36 of human immunodeficiency virus; a composite thereof; and an anti-HIV agent or preventive or remedy for AIDS which contains the polypeptide or composite. (Y')m1-X1aX1b-A1-X1cX1dX1e-A2-(X')n1 : modular structure 1 (MS1) (Y')m2-X2a-A1A1-X2bX2c-A2A2-(X')n2 : modular structure 2 (MS2) (Y')m3-X3a-A1-X3bX3cX3d-A2-X' : modular structure 3 (MS3) {In the modular structures, A1 represents an acidic amino acid; A2 represents a basic amino acid; X1a to X3d are the same or different and each represents any desired amino acid; X' represents any desired amino acid which may have a protective group or represents -OR1 or -NR2R3; X' represents -OR4 or -NR5R6 (R1 to R6 are the same or different and each represents hydrogen, alkyl, aryl, or aralkyl); Y' represents hydrogen, R7CO- (R7 represents alkyl, optionally substituted phenyl, or optionally substituted benzyl), toluenesulfonyl, or methanesulfonyl; n1 and n2 each is 1 when MS1 and MS2 are terminated by carbon, and each is 0 when MS1 and MS2 are not terminated by carbon; m1 to m3 each is 1 when MS1, MS2, and MS3 are terminated by nitrogen, and each is 0 when MS1, MS2, and MS3 are not terminated by nitrogen; and in the modular structures (1) to (3) the amino acids each means -NH-CH(R')-CO- (R' represents a side chain of the amino acid).}