发明名称 |
Pyridones and their use as modulators of serine hydrolase enzymes |
摘要 |
This invention relates to a compound of formula I:or a pharmaceutically acceptable salt thereof;in which preferably R3, R4 and R6 are each hydrogen;X is C=O or CH2; andR7 and R8 are each independently selected from the group consisting of hydrogen, (C1-C12)alkyl, (C3-C8)cycloalkyl and (C1-C12)alkyl (C6-C14)aryl; orR7 and R8 when taken together form a (C2-C7)alkylene group; or-NR7R8 together forms a (C2-C14)heterocyclic or substituted (C2-C14)heterocyclic. Such compounds modulate the activity of serine hydrolases and can be used in pharmaceutical compositions for the treatment of Alzheimer's disease.
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申请公布号 |
US6544986(B2) |
申请公布日期 |
2003.04.08 |
申请号 |
US20010973539 |
申请日期 |
2001.10.09 |
申请人 |
DALHOUSIE UNIVERSITY |
发明人 |
DARVESH SULTAN;MAGEE DAVID;VALENTA ZDENEK;MARTIN EARL |
分类号 |
A61P25/28;C07D213/64;C07D413/12;C07D417/12;(IPC1-7):A61K31/54;A61K31/44;C07D411/00;C07D279/14;C07D223/04 |
主分类号 |
A61P25/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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