COHALOGENATIONS OF SELECTED DOUBLE BONDED COMPOUNDS USING N-HALO-SUCCINIMIDE.

摘要

The present invention relates to a method of producing a cohalogenated compound by adding halogen(s) and another group(s) to a multiple bond in an initial compound, the method characterised by the step of reacting the initial compound with a primary reagent in the presence of a catalyst wherein the primary reagent reacts with the multiple bond to produce the cohalogenated compound. In preferred embodiments, the catalyst is hypophosphorous acid, the primary reagent consists of N-halo-succinimide and acetone and the initial compound is organic. This method is particularly applicable for the production of cohalogenated steroids, including lanosterol.