发明名称 |
COISOGENIC EUKARYOTIC CELL COLLECTIONS |
摘要 |
Collections of cultured eukaryotic cells, particularly human cells, in which the cells are coisogenic at a common target locus, are provided. Particularly provided are collections of coisogenic cells that differ in genomic sequence by no more than 0.05%, excluding changes at the target locus, collections in which the coisogenic cells differ in genomic sequence by no more than 0.005%, excluding changes at the target locus, and collections in which the cells jack heterologous genetic elements within 10 kilobases of the coisogenic target locus. Kits comprising the cell collections, methods of making the collections, kits for making the collections, and methods of using the collections to facilitate pharmacogenomic analyses are presented. Preferred target loci at which the cells are coisogenic include genes that affect drug resistance, drug sensitivity, and/or drug metabolism. |
申请公布号 |
WO03027264(A2) |
申请公布日期 |
2003.04.03 |
申请号 |
WO2002US31180 |
申请日期 |
2002.09.27 |
申请人 |
UNIVERSITY OF DELAWARE;KMIEC, ERIC, B.;RICE, MICHAEL, C. |
发明人 |
KMIEC, ERIC, B.;RICE, MICHAEL, C. |
分类号 |
C12N;C12N1/18;C12N5/06;C12N5/08;C12N5/10;C12N5/12;C12Q1/68;G01N33/53 |
主分类号 |
C12N |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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