| 摘要 |
PURPOSE: A cancer diagnosing method by using extracellular cyclic adenosine monophosphate(cAMP)-dependent protein kinase A is provided to determine various kinds of cancer besides breast cancer at an early stage and is potentially useful in the treatment and prognosis of the cancer in a patient by reducing the level of extraPKA by down-regulation, such as by delivering the RII beta subunit of PKA-II to target cancer cells. CONSTITUTION: A method of diagnosing cancer in a patient which method comprises assaying a sample from a cancer patient for the presence of extracellular cAMP-dependent protein kinase A(ECPKA), wherein the presence of an elevated level of ECPKA in sample compared to the level of cAMP-dependent extraPKA in a control sample is quantitatively indicative of cancer in the patient, the level of cAMP-dependent extraPKA in control sample is from about 0 to about 1.0mUnits/ml blood serum or urine, and the cancer is breast cancer, prostate cancer, ovarian cancer, or bladder cancer.
|
