USE OF RADIOPHARMACEUTICAL COMPLEXES IN ACHIEVING TRANSPLANTATION TOLERANCE

摘要

Non-lethal methods of conditioning a recipient prior to bone marrow transplantation to achieve highly enhanced, stable, long-term hematopoietic chimerism in presence of transient immunosuppression are described. In particular, the administration of non-lethal doses of bone-seeking radiopharmaceuticals such as <153>Samarium Lexidronam, a radioactive compound linked to a tetraphosphonate group, to target bone marrow cells, are disclosed herein.