摘要 |
A hydroxyeicosenoic acid analog represented by the following Formula (I), the bond represents a cis-vinylene group or an ethynylene group; Y represents CH<2>, O or S(O)<p> wherein p is 0, 1 or 2; m represents an integer of 1 to 4 inclusive; n represents an integer of 0 to 3 inclusive; the sum of m and n is an integer of 3 to 7 inclusive; R<1> represents a C<1-4> alkyl group or a C<3-8> cycloalkyl group; R<2> represents a hydrogen atom or a methyl group; R<3> represents COR<4>, a nitrile group, a halogen atom, a tetrazole group or a thiazolidinedione group; R<4> represents OR<6>, NHR<6>, N(OH)R<6>, NHSO<2>R<5>, glycerol or functionalized glycerols; R<5> represents a C1-15 alkyl group, a C6-10 aryl group or a C7-14 aryl group substituted with alkyl groups, halogens or amino groups; R<6> represents a hydrogen, a C1-10 alkyl group or a C1-10 alkyl group substituted with a hydroxyl group, or a pharmaceutically acceptable salt or hydrate thereof. The compounds of the present invention are useful as an elastase release inhibitor. |
申请人 |
TAISHO PHARMACEUTICAL CO., LTD.;BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;FALCK, JOHN, R.;MIYATA, NORIYUKI;ONO, NAOYA;CHONAN, TOMOMICHI;HIRANO, HITOMI;TODA, YOSHIHISA;TANAMI, TOHRU;OKUYAMA, SHIGERU |
发明人 |
FALCK, JOHN, R.;MIYATA, NORIYUKI;ONO, NAOYA;CHONAN, TOMOMICHI;HIRANO, HITOMI;TODA, YOSHIHISA;TANAMI, TOHRU;OKUYAMA, SHIGERU |