Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives

摘要

The present invention is a compound of formula wherein R1 is halogen or lower alkyl; R2 is hydrogen, lower alkyl, cycloalkyl, -(CH2)m-phenyl, wherein the phenyl ring may be substituted by lower alkoxy, or is -(CH2)m-indolyl; R3 is -C(O)O-lower alkyl, -C(O)OH, or a five membered heteroaromatic group, which rings may be substituted by lower alkyl or cycloalkyl; n is 0, 1 or 2; m is 0, 1 or 2; or a pharmaceutically acceptable acid addition salt thereof. Compound I shows high affinity and selectivity for GALA A alpha5 receptor binding sites.