摘要 |
The present invention relates to a process for extracting beneficial compounds, in particular growth factors, such as TGF beta and IGF-1 from milk. In this process a hydrophobic interaction chromatography step is included. A resin having a butyl group, or a phenyl group as the ligand is used as hydrophobic interaction resin. The resin can be eluted with a salt gradient which, when the ligand is a phenyl group, contains substantially no alcohol, and thus resulting in fractions enriched in the desired growth factors. These fractions can be separated further by means of a hydroxyapatite column. |
申请人 |
CAMPINA B.V.;NUMICO RESEARCH B.V.;KIVITS, MARINUS, GERARDUS, CORNELIS;GALAMA, CATHARINA, MARINA;HENDRIKS, ANDOR, WILHELM, JOSEPH |
发明人 |
KIVITS, MARINUS, GERARDUS, CORNELIS;GALAMA, CATHARINA, MARINA;HENDRIKS, ANDOR, WILHELM, JOSEPH |