A SCREENING SYSTEM FOR IDENTIFYING DRUG-DRUG INTERACTIONS AND METHODS OF USE THEREOF

摘要

The invention features a method of screening for drug-drug interactions usin g combinational arrays. The method includes the steps of: (a) providing (i) a test drug; (ii) a drug library; and (iii) an assay, (b) contacting the test drug and at least some of the library drugs from the drug library in the ass ay under conditions that ensure that each test drug/library drug contacting is segretated from the others, (c) recording the result of the contacting of th e test drug and the library drug in the assay, and (d) identifying combination s of drugs that produce a result in the assay that is different from the resul ts produced by either drug of the combination by itself. According to the metho d, each of the identified combinations indicates an interaction between the tes t drug and the library drug.