发明名称 2,4-DIAMINOPYRIMIDINE DERIVATIVES
摘要 The present invention is concerned with compounds of general formula (I), wherein R1 signifies lower-alkoxy, R2 signifies bromine, lower-alkoxy or hydroxy, R3 signifies hydrogen, lower-alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl or cyano, R4 and R5 each independently signify hydrogen, lower-alkyl, lower-alkoxy, halogen, hydroxy, amino, di(lower alkyl )- amino, cyano or nitro and Q signifies ethynylene or vinylene, pharmaceutical ly usable salts thereof, the use of these compounds and their salts as therapeutically active substances; medicaments based on these substances and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula (I) and their pharmaceutically acceptable salts and intermediates for their manufacture.
申请公布号 CA2254117(C) 申请公布日期 2003.03.11
申请号 CA19972254117 申请日期 1997.05.07
申请人 F. HOFFMANN-LA ROCHE AG 发明人 GUERRY, PHILIPPE;STALDER, HENRI;WYSS, PIERRE-CHARLES
分类号 A61K31/00;A61K31/505;A61K31/506;A61K31/535;A61K31/5375;A61K31/5377;A61P31/00;A61P31/04;C07D217/06;C07D401/04;C07D401/10;C07D401/14;C07D405/14;C07D409/04;C07D409/14;C07D417/04;C07D417/14;(IPC1-7):C07D401/10;C07D413/14;C07D217/22;A61K31/53 主分类号 A61K31/00
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