An affinitive linker is introduced into a target substance and captured by a binding partner capable of binding to the affinitive linker to thereby select a binding molecule capable of binding to the target substance. For example, a sugar chain contained in an influenza virus antigen is labeled with an affinitive linker such as biotin and allowed to bind to streptpavidin serving as a binding partner and then recovered. Thus, an antibody binding to the antigen can be easily concentrated. This method of selecting a binding molecule is useful in screening a neutralizer.
申请公布号
WO03019187(A1)
申请公布日期
2003.03.06
申请号
WO2002JP08256
申请日期
2002.08.13
申请人
INSTITUTE FOR ANTIBODIES CO., LTD;KUROSAWA, YOSHIKAZU;AKAHORI, YASUSHI;HIRONO, YUKARI;KAKITA, MAI;SUZUKI, KAZUHIRO;OKUNO, YOSHINOBU