The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can be used in various aspects of biological research, diagnosis and medical treatment
申请公布号
WO03018771(A2)
申请公布日期
2003.03.06
申请号
WO2002US27220
申请日期
2002.08.26
申请人
GENENTECH, INC.;ANDERSEN, DANA, C.;SIMMONS, LAURA, C.