发明名称 |
AN IMPROVED PROCESS FOR THE PREPARATION OF AMORPHOUS ATORVASTATIN CALCIUM SALT (2:1) |
摘要 |
Improved process for the preparation of amorphous atorvastatin calcium salt (2:1) comprises hydrolyzing the lactone form of atorvastatin of formula of Fig. 1 with aqueous alkali or alkaline earth metal base, extracting with organic solvent the reaction mixture and adding the same to an anti-solvent to precipitate the product and finally filtering the product to afford amorphou s atorvastatin calcium (2:1). The process also comprises the preparation of amorphous atorvastatin calcium salt (2:1) from its crystalline form.
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申请公布号 |
CA2456095(A1) |
申请公布日期 |
2003.03.06 |
申请号 |
CA20012456095 |
申请日期 |
2001.08.31 |
申请人 |
MOREPEN LABORATORIES LTD. |
发明人 |
SURI, SANJAY;SINGH, JUJHHAR;BANSAL, BALDEV RAJ;SARIN, GURDEEP SINGH |
分类号 |
C07D207/34;C07D207/40;C07D207/416;C07D409/06;(IPC1-7):C07D207/34;A61P3/06;A61K31/40 |
主分类号 |
C07D207/34 |
代理机构 |
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