发明名称 |
ANTIBODIES TO TRUNCATED VEGF-D AND USES THEREOF |
摘要 |
The invention is based on the isolation of antibodies that were made to a polypeptide having the amino acid sequence for a truncated VEGF-D. One of these antibodies can interfere with the activity of VEGF-D mediated by VEGFR-2 and interfere with the binding of VEGF-D to VEGFR-3 but does not interfere with the activity of VEGF mediated by VEGFR-2 or bind to VEGF-C. The invention provides pharmaceutical and diagnostic compositions and methods utilizing these antibodies. |
申请公布号 |
EP1140175(A4) |
申请公布日期 |
2003.03.05 |
申请号 |
EP19990969995 |
申请日期 |
1999.12.21 |
申请人 |
LUDWIG INSTITUTE FOR CANCER RESEARCH |
发明人 |
ACHEN, MARC G.;STACKER, STEVEN ALAN |
分类号 |
G01N33/53;A61K39/00;A61K39/395;A61P9/00;A61P11/00;A61P17/06;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P41/00;A61P43/00;C07K16/18;C07K16/24;C12N5/10;C12N15/02;C12P21/08;G01N33/577 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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