NOVEL PROPENOHYDROXAMIC ACID DERIVATIVES

摘要

Propenohydroxamic acid derivatives represented by the following general formula (1) or salts thereof and drugs containing the same: (1) wherein R1 represents hydrogen, alkyl or halogeno; R2 represents cycloalkyl, aryl, heteroaryl, etc.; R3 represents hydrogen, alkenyl, etc.; R5 represents R6CO- , R6SO2-, R6NHCO- or R6NHCS- (wherein R6 represents alkyl, cycloalkyl, cyclic amino, aryl, heteroaryl, etc.); R7 represents hydrogen or a protective group ; and A represents CH, nitrogen or oxidized nitrogen. Because of having an excellent TACE inhibitory activity, the above compounds are useful as drugs for preventing and/or treating diseases such as sepsis, rheumatoid arthritis , arthritis deformans, infectious diseases, autoimmune diseases, malignant neoplasm, collagen disease, ulcerative colitis, MOF, non-insulin-dependent diabetes mellitus, etc.