发明名称 |
Drospirenone for hormonal substitution therapy |
摘要 |
<p>The present invention relates to compositions comprising drospirenone together with a pharmaceutically acceptable carrier of excipient, wherein said composition does not contain an estrogen. In one embodiment drospirenone is in micronized form. In another embodiment drospirenone is in a form having a surface area of more than 10,000 cm 2 /g. In a further embodiment drospirenone is in a form having rapid dissolution such that at least 70% of said drospirenone is dissolved within 30 minutes when the composition is subjected to dissolution testing in 900 ml of water at 37 °C using USP XXIII Paddle Method II operated at a stirring rate of 50 rpm. In a still further embodiment the composition comprises inert carrier particles containing drospirenone on their surface.</p> |
申请公布号 |
CZ20022411(A3) |
申请公布日期 |
2003.02.12 |
申请号 |
CZ20020002411 |
申请日期 |
2001.01.18 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
HEIL WOLFGANG;HILMANN JURGEN;LIPP RALPH;SCHURMANN ROLF |
分类号 |
A61J7/00;A61J1/14;A61K9/14;A61K9/70;A61K31/565;A61K31/585;A61P5/30;A61P9/00;A61P15/00;A61P15/12;A61P17/00;A61P25/00;A61P25/22;(IPC1-7):A61K31/585 |
主分类号 |
A61J7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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