SOLUBLE BETA AMYLOID PRECURSOR PROTEIN SECRETION PROMOTERS

摘要

According to the present invention, there are provided compounds represented by formula (I): <CHEM> Äwherein R<1> and R<2> represent hydrogen atom, a lower alkyl group, etc.; ring A is an optionally substituted benzene ring, X is oxygen atom, etc.; and Y represents CH or NÜ or salts thereof, or prodrugs thereof, and use thereof as well as processes of manufacturing these compounds. The compounds of the present invention and the like possess a potent soluble beta amyloid precursor protein secretion promoting activity and suppress the functional disorders or apoptosis of cells, in particular neurons, mediated by the secreted soluble beta amyloid precursor proteins having a neurotrophic factor like property.