IL-6 SIGNAL TRANSMISSION-ANTAGONIZING PEPTIDE

摘要

PROBLEM TO BE SOLVED: To provide a peptide which has a relatively low mol.wt. and can be used for preventing and treating diseases accompanied of the abnormal production of IL-6. SOLUTION: This IL-6 signal transmission-antagonizing peptide has the following characteristics. (1) The IL-6 signal transmission-antagonizing peptide bound to an IL-6 receptor exhibits an IL-6 function-inhibiting action on the three- dimensional structure. (2) The basic primary structure of the specific three- dimensional structure formation contains a 6 to 9 amino acid sequence whose both ends are nipped with cysteine molecules. (3) The amino acid sequence has a mol.wt. of <=3 kd. The IL-6 signal transmission-antagonizing peptide is an IL-6-binding motif peptide having a human IL-6 signaling-inhibiting action against the human IL-6 receptor.