USE OF MATRIX METALLOPROTEINASE INHIBITORS TO MITIGATE NERVE DAMAGE

摘要

This invention pertains to the discovery that inhibitors of matrix metalloproteinases (e.g. MMP-9) can reduce neurological damage (e.g. secondary damage) following trauma to nervous tissue in a mammal, and/or reduce abnormal vascular permeability associated with spinal cord injury, and/or improving recovery of neurological function following injury to neurological tissue. Methods of use of matrix metalloproteinase inhibitors for such applications are provided.