NOVEL CELL CYCLE REGULATOR INHIBITOR HY52, PREPARATION METHOD THEREOF AND USE THEREOF AS ANTICANCER AGENT

摘要

PURPOSE: A novel compound for a cell cycle regulator and a cdc2 and cdk2 protein phosphorylation enzyme inhibitor and its preparation method are provided, wherein the compound shows the anticancer activity. CONSTITUTION: The compound(HY52) is represented by the formula 1. Preferably the pharmaceutical salt of the compound is an inorganic salt comprising HCl, sulfuric acid and phosphoric acid and an organic salt comprising oxalic acid, fumaric acid, maleic acid, malic acid, citric acid, tartaric acid and glutamic acid. The preparation method comprises the steps of extracting Pata de Vaca(Bauhinia forficata) by using a solvent; filtering the extract and concentrating the filtered one; and purifying the concentrated one by chromatography. Preferably the solvent for extraction is selected from the group consisting of an alcohol; a fluorinated hydrocarbon; tetrahydrofuran, DMF, DMSO and ethyl acetate.