| 摘要 |
The invention relates to the preparation of novel polyamines, such as derivatives of 1,3-bis-[(2'-aminoethyl)-amino]propane (2,3,2-tetramine) and 1,4,8,11-tetraazacyclotetradecane (cyclam), which can be used to treat mitochondrial and degenerative diseases. Accordingly, in one aspect the invention is directed to compounds of the formula: wherein R1, R2, R3, R4, R5 and R6 may be the same or different and are hydrogen, alkyl, aryl, cycloalkyl, amino acid, glutathione, urate, ascorbate, estrogen, dehydroepiandrosterone, redox stabilizing substituents, a quinone, glutamate, succinate, -(CH2)n[XCH2)n]NH2- wherein n=3-6 and X=nitrogen, sulfur, phosporous or carbon, or heterocycle wherein R1 to R6 taken together are -(CH2XCH2)n- wherein n=3-6 and X=nitrogen, sulfur, phosporous or carbon. M, n, and p may be the same or different and are bridging groups of variable length from 3-12 carbons. X1 and X2 may be the same or different and are nitrogen, sulfur, phosporous or carbon.
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