CALCIUM L-THREONATE FOR PREVENTING OR TREATING CARTILAGE RELATED DISEASES

摘要

The present invention relates to calcium L-threonate compound for preventing or treating cartilage related diseases, a pharmaceutical composition comprising the same and use of the same. It had been demonstrated by experiments that calcium L-threonate could improve significantly the positiv e expression percentage of collagen I mRNA in the chondrocyte and osteoblast, improved significantly the positive expression percentage of articular cartilage and epiphyseal cartilage, facilitated the growth of chondrocyte, increased the quantity of bone collagen, promoted the formation of bone and cartilage matrix and the synthesis of proteoglycan. It could also promote th e formation of bone nourishing blood vessels and improve the microcirculation of bone.