发明名称 |
HYPOGLYCAEMIC PEPTIDES AND METHODS OF USE THEREOF |
摘要 |
A peptide of the formula (Xaa)n1-Xaa1-His-Thr-Asp-(Xaa)n2, wherein Xaa is any amino acid; Xaa1 is a hydrophobic amino acid, preferably Gly or Val; n1 is 0-10; and n2 is 0-10; and use thereof in regulating in vivo blood glucose levels in a human or other mammal, particularly in the treatment of Type 2 diabetes in a human. Preferably, the peptide is a tetrapeptide selected from Gly-His-Thr-Asp and Val-His-Thr-Asp. These hypoglycaemic peptides are isolated from human urine and they also have been chemically synthesized.
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申请公布号 |
WO03002594(A1) |
申请公布日期 |
2003.01.09 |
申请号 |
WO2002AU00840 |
申请日期 |
2002.06.27 |
申请人 |
INTERNATIONAL DIABETES INSTITUTE;MONASH UNIVERSITY;ZIMMET, PAUL, ZEV;NG, FRANK, MAN-WOON |
发明人 |
ZIMMET, PAUL, ZEV;NG, FRANK, MAN-WOON |
分类号 |
A61K38/00;A61K38/07;A61K38/08;A61P5/50;C07K5/02;C07K5/103;C07K5/113;C07K7/04;(IPC1-7):C07K7/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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