Fiber-coupled, high-speed, angled-dual-axis optical coherence scanning microscopes

摘要

This invention provides an angled-dual-axis optical coherence scanning microscope comprising a fiber-coupled, high-speed angled-dual-axis confocal scanning head and a vertical scanning unit. The angled-dual-axis confocal scanning head is configured such that an illumination beam and an observation beam intersect optimally at an angle theta within an object and the scanning is achieved by pivoting the illumination and observation beams jointly using a high-speed scanning element. The vertical scanning unit causes the angled-dual-axis confocal scanning head to move towards or away from the object, thereby yielding a vertical cross-section scan of the object, while keeping the optical path lengths of the illumination and observation beams unchanged. By incorporating MEMS scanning mirrors and fiber-optic components, the angled-dual-axis optical coherence scanning microscope of the present invention can be miniaturized to provide a particularly powerful tool for in vivo medical imaging applications.