发明名称 APPLICATION OF THIAZOLIDINEDIONES FOR PREVENTION OR ONSET POSTPONEMENT OF INSULIN-INDEPENDENT DIABETES MELLITUS (NIDDM)
摘要 FIELD: organic chemistry, medicine, endocrinology. SUBSTANCE: invention proposes a novel method of treatment of damaged tolerance to glucose in order to prevention or onset postponement of insulin-independent diabetes mellitus that involves administration of compounds of the general formula: or its tautomeric form, and/or solvate where A5 means substituted or unsubstituted aromatic hydrocarbon group; A6 means benzene ring having up to 5 substitutes; X6 means O, S or NR32 where R32 means hydrogen atom, alkyl, acyl, aralkyl where aryl moiety can be substituted or unsubstituted, or substituted or unsubstituted aryl group; Y2 means O or S; R31 means alkyl, aralkyl or aryl; n = a whole number in the range form 2 to 6. EFFECT: expanded assortment of agents of claimed designation, valuable medicinal properties of compounds. 2 cl, 4 tbl, 1 ex
申请公布号 RU2195282(C2) 申请公布日期 2002.12.27
申请号 RU19960108256 申请日期 1994.09.14
申请人 SANKIO KOMPANI LIMITED 发明人 OLEFSKI DZHEROL'D;ANTONUCHI TEHMMI;LOKVUD DIN;NORRIS REBEKKA
分类号 C07D277/20;A61K31/41;A61K31/42;A61K31/421;A61K31/423;A61K31/425;A61K31/426;A61K31/427;A61K31/44;A61K31/4439;A61K31/495;A61K31/505;A61P3/06;A61P3/08;A61P3/10;A61P5/50;A61P9/12;A61P13/02;A61P15/00;A61P25/02;A61P43/00;C07D263/44;C07D263/56;C07D277/34;C07D291/04;C07D413/14;C07D417/06;C07D417/10;C07D417/12;(IPC1-7):A61K31/426 主分类号 C07D277/20
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