发明名称 |
METHOD OF PROVIDING POLYPEPTIDE PREPARATIONS WITH REDUCED ENZYMATIC SIDE ACTIVITIES |
摘要 |
A method of providing polypeptide preparations having a reduced content of undesired enzymatic side activities, the method comprising subjecting a medium containing a desired polypeptide such as an enzyme, a pharmaceutically active or immunologically active polypeptide to a pH of less than 2 for a period of time that is required to inactivate the side activities whilst retaining the activity of the desired polypeptide. The method is useful for providing milk clotting enzyme products including rennets or coagulants based on chymosin or pepsin or microbial aspartic proteases e.g. derived from bacterial species and species of filamentous fungi. |
申请公布号 |
WO02064759(A3) |
申请公布日期 |
2002.12.27 |
申请号 |
WO2002DK00083 |
申请日期 |
2002.02.06 |
申请人 |
CHR. HANSEN A/S;HARBOE, MARIANNE, KIRSTEN |
发明人 |
HARBOE, MARIANNE, KIRSTEN |
分类号 |
C12N9/64;C12N9/99 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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