发明名称 |
METHODS FOR MODULATING GAP JUNCTIONS |
摘要 |
<p>A method for modulating gap junctions is provided. In a first step, the transcription of connexin is enhanced and the gap junction is relocalized at the cell membrane; in a second step, gap junction function is restored by properly gating the channel and/or inducing apoptosis. The method preferably comprises a providing a cell or an animal with a first compound for increasi ng the activity of protein kinase A (PKA) and in the second step providing the cell or animal with a second compound for specifically inhibiting or activating one or more protein kinase C (PKC) isoforms and/or for specifical ly inhibiting p38 MAP kinase.</p> |
申请公布号 |
CA2450159(A1) |
申请公布日期 |
2002.12.27 |
申请号 |
CA20022450159 |
申请日期 |
2002.06.14 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
JOUISHOMME, HERVE;SIDDIQI, SABA;BELGOUDI, JAAFAR;LACELLE, SUZANNE;ARNOLD, JENNIFER;PHIPPS, JENNY;BELBARAKA, LOUBABA |
分类号 |
A61K31/00;A61K31/137;A61K31/352;A61K31/522;A61K31/70;A61K31/7076;A61K45/06;A61P35/00;C07K14/705;C12N9/12;C12Q1/48;G01N33/50;(IPC1-7):C12N9/12;G01N33/573;G01N33/68 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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